What is the correct fridge temperature range for controlled drugs?

• A. -10 to 0 degrees C
• B. 0-5 degrees C
• C. 2-8 degrees C
• D. 4-10 degrees C

Answer: (C)

Controlled drugs need to be kept in a fridge that stays cool but not frozen, to preserve potency and safety. The 2–8°C range is the standard because it sits well above freezing while staying cool enough to prevent gradual degradation that can occur at higher temperatures. This narrow band helps ensure the medicines remain stable over time and aligns with regulatory expectations for monitoring, recording, and secure storage. Ranges like -10 to 0°C risk freezing the product, which can damage the formulation, while higher ranges (such as 0–5°C or 4–10°C) allow temperatures that may lead to potency loss. In practice, use a calibrated fridge set to 2–8°C, with continuous monitoring and an alarm for any deviation, and always follow the specific storage instructions on each product.